Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened

Inappropriate activation of the Hedgehog (Hh) signaling pathway in skin is critical for the development of basal cell carcinomas (BCCs). We have investigated the anti-BCC efficacy of topically-applied CUR61414, an inhibitor of the Hedgehog signal transduction molecule Smoothened. In mice, topical CU...

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Autors principals: Tang, Tracy, Tang, Jean Y., Li, Dongwei, Reich, Mike, Callahan, Christopher A., Fu, Ling, Yauch, Robert L., Wong, Frank, Kotkow, Karen, Chang, Kris, Shpall, Elana, Wu, Angela, Rubin, Lee L., Marsters, James C, Epstein, Ervin H., Caro, Ivor, de Sauvage, Frederic J.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113453/
https://ncbi.nlm.nih.gov/pubmed/21558397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-3370
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