Inhibition of interleukin-6 trans-signaling in the brain facilitates recovery from lipopolysaccharide-induced sickness behavior

BACKGROUND: Interleukin (IL)-6 is produced in the brain during peripheral infection and plays an important but poorly understood role in sickness behavior. Therefore, this study investigated the capacity of soluble gp130 (sgp130), a natural inhibitor of the IL-6 trans-signaling pathway to regulate I...

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Detalhes bibliográficos
Main Authors: Burton, Michael D, Sparkman, Nathan L, Johnson, Rodney W
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113341/
https://ncbi.nlm.nih.gov/pubmed/21595956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-54
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