Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1

BACKGROUND: Progression of pancreatic ductal adenocarcinoma (PDAC) is largely the result of genetic and/or epigenetic alterations in the transforming growth factor-beta (TGF-β)/Smad signalling pathway, eventually resulting in loss of TGF-β-mediated growth arrest and an increase in cellular migration...

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Main Authors: Ungefroren, Hendrik, Groth, Stephanie, Sebens, Susanne, Lehnert, Hendrik, Gieseler, Frank, Fändrich, Fred
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3112431/
https://ncbi.nlm.nih.gov/pubmed/21624123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-67
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