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Structure of estradiol metal chelate and estrogen receptor complex: The basis for designing a new class of selective estrogen receptor modulators
Selective estrogen receptor modulators, such as estradiol 17α-derived metal complexes, have been synthesized as targeted probes for the diagnosis and treatment of breast cancer. Here, we report the detailed 3D structure of estrogen receptor alpha ligand-binding domain (ERα-LBD) bound with a novel es...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3112352/ https://ncbi.nlm.nih.gov/pubmed/21473635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200192y |
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