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Increased sensitivity to antigen in high avidity CD8(+) T cells results from augmented membrane proximal T-cell receptor signal transduction
The functional avidity of a cytotoxic T lymphocyte (CTL) is known to be a critical determinant of the efficacy with which it clears pathogens. High avidity cells, which are by definition highly sensitive to peptide antigen, are superior for elimination of viruses and tumours. Our studies have establ...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3112340/ https://ncbi.nlm.nih.gov/pubmed/21501160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2011.03440.x |
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