Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk

AIMS: The level of inhibition of the human Ether-à-go-go-related gene (hERG) channel is one of the earliest preclinical markers used to predict the risk of a compound causing Torsade-de-Pointes (TdP) arrhythmias. While avoiding the use of drugs with maximum therapeutic concentrations within 30-fold...

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Detalhes bibliográficos
Main Authors: Mirams, Gary R., Cui, Yi, Sher, Anna, Fink, Martin, Cooper, Jonathan, Heath, Bronagh M., McMahon, Nick C., Gavaghan, David J., Noble, Denis
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3112019/
https://ncbi.nlm.nih.gov/pubmed/21300721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvr044
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