A novel site of antibiotic action in the ribosome: Interaction of evernimicin with the large ribosomal subunit

Evernimicin (Evn), an oligosaccharide antibiotic, interacts with the large ribosomal subunit and inhibits bacterial protein synthesis. RNA probing demonstrated that the drug protects a specific set of nucleotides in the loops of hairpins 89 and 91 of 23S rRNA in bacterial and archaeal ribosomes. Spo...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Belova, Larissa, Tenson, Tanel, Xiong, Liqun, McNicholas, Paul M., Mankin, Alexander S.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2001
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC31120/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11259679/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.071527498
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