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Protein kinase C epsilon contributes to basal and sensitizing responses of TRPV1 to capsaicin in rat dorsal root ganglion neurons

Phosphorylation of the vanilloid receptor (TRPV1) by protein kinase C epsilon (PKCε) plays an important role in the development of chronic pain. Here, we employ a highly defective herpes simplex virus vector (vHDNP) that expresses dominant negative PKCε (DNPKCε) as a strategy to demonstrate that PKC...

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Detalhes bibliográficos
Main Authors: Srinivasan, Rahul, Wolfe, Darren, Goss, James, Watkins, Simon, de Groat, William C., Sculptoreanu, Adrian, Glorioso, Joseph C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111963/
https://ncbi.nlm.nih.gov/pubmed/18973552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1460-9568.2008.06438.x
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