Chromosome Damage and Repair in Children with Sickle Cell Anaemia and Long-Term Hydroxycarbamide Exposure

Hydroxycarbamide (hydroxyurea) provides laboratory and clinical benefits for adults and children with sickle cell anaemia (SCA). Given its mechanism of action and prior reports of genotoxicity, concern exists regarding long-term toxicities and possible carcinogenicity. We performed cross-sectional a...

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Bibliografiske detaljer
Main Authors: McGann, Patrick T., Howard, Thad A., Flanagan, Jonathan M., Lahti, Jill M., Ware, Russell E.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111895/
https://ncbi.nlm.nih.gov/pubmed/21542824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2011.08698.x
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