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Chromosome Damage and Repair in Children with Sickle Cell Anaemia and Long-Term Hydroxycarbamide Exposure

Hydroxycarbamide (hydroxyurea) provides laboratory and clinical benefits for adults and children with sickle cell anaemia (SCA). Given its mechanism of action and prior reports of genotoxicity, concern exists regarding long-term toxicities and possible carcinogenicity. We performed cross-sectional a...

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Detalhes bibliográficos
Main Authors: McGann, Patrick T., Howard, Thad A., Flanagan, Jonathan M., Lahti, Jill M., Ware, Russell E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111895/
https://ncbi.nlm.nih.gov/pubmed/21542824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2011.08698.x
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