Granulocyte-Macrophage Colony Stimulating Factor Blockade Promotes CCR9(+) Lymphocyte Expansion in Nod2 Deficient Mice

BACKGROUND: Ileal involvement in Crohn’s disease (CD) is associated with NOD2 mutations and Granulocyte-Macrophage Colony Stimulating Factor auto-antibodies (GM-CSF Ab), and GM-CSF blockade promotes ileitis in Nod2/Card15 deficient (C15KO) mice. RALDH2 expressing dendritic cells (DC) and IL-4 promot...

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Detalhes bibliográficos
Main Authors: Samson, Charles M., Jurickova, Ingrid, Molden, Erin, Schreiner, William, Colliver, Joshua, Bonkowski, Erin, Han, Xiaonan, Trapnell, Bruce C., Denson, Lee A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111853/
https://ncbi.nlm.nih.gov/pubmed/21381154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ibd.21672
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