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Testing the Ortholog Conjecture with Comparative Functional Genomic Data from Mammals
A common assumption in comparative genomics is that orthologous genes share greater functional similarity than do paralogous genes (the “ortholog conjecture”). Many methods used to computationally predict protein function are based on this assumption, even though it is largely untested. Here we pres...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3111532/ https://ncbi.nlm.nih.gov/pubmed/21695233 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002073 |
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