Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M

Protection of the endothelium is provided by circulating sphingosine-1-phosphate (S1P), which maintains vascular integrity. We show that HDL-associated S1P is bound specifically to both human and murine apolipoprotein M (apoM). Thus, isolated human ApoM(+) HDL contained S1P, whereas ApoM(−) HDL did...

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Bibliographic Details
Main Authors: Christoffersen, Christina, Obinata, Hideru, Kumaraswamy, Sunil B., Galvani, Sylvain, Ahnström, Josefin, Sevvana, Madhumati, Egerer-Sieber, Claudia, Muller, Yves A., Hla, Timothy, Nielsen, Lars B., Dahlbäck, Björn
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111292/
https://ncbi.nlm.nih.gov/pubmed/21606363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1103187108
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