Chargement en cours...

Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses

The SNP (c.1142G > A;p.R381Q) in the IL-23 receptor (IL23R) confers protection from multiple inflammatory diseases, representing one of the most significant human genetic polymorphisms in autoimmunity. We, therefore, sought to define the functional consequences of this clinically significant vari...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Sarin, Ritu, Wu, Xingxin, Abraham, Clara
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111257/
https://ncbi.nlm.nih.gov/pubmed/21606346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017854108
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!