The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans

IL-23 and Th17 cells are key players in tissue immunosurveillance and are implicated in human immune-mediated diseases. Genome-wide association studies have shown that the IL23R R381Q gene variant protects against psoriasis, Crohn's disease and ankylosing spondylitis. We investigated the immuno...

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Detalhes bibliográficos
Main Authors: Di Meglio, Paola, Di Cesare, Antonella, Laggner, Ute, Chu, Chung-Ching, Napolitano, Luca, Villanova, Federica, Tosi, Isabella, Capon, Francesca, Trembath, Richard C., Peris, Ketty, Nestle, Frank O.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3043090/
https://ncbi.nlm.nih.gov/pubmed/21364948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017160
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