The IL23R A/Gln381 Allele Promotes IL-23 Unresponsiveness in Human Memory T-Helper 17 Cells and Impairs Th17 Responses in Psoriasis Patients

We and others have shown that the minor, nonconserved allele Gln381 of the Arg381Gln single-nucleotide polymorphism (rs11209026G>A) of the IL-23 receptor gene (IL23R) protects against psoriasis. Moreover, we have recently shown impaired IL-23-induced IL-17A production and STAT-3 phosphorylation i...

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Detalhes bibliográficos
Main Authors: Di Meglio, Paola, Villanova, Federica, Napolitano, Luca, Tosi, Isabella, Terranova Barberio, Manuela, Mak, Rose K, Nutland, Sarah, Smith, Catherine H, Barker, Jonathan N W N, Todd, John A, Nestle, Frank O
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778837/
https://ncbi.nlm.nih.gov/pubmed/23563201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2013.170
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