The AIM2 inflammasome is critical for innate immunity against Francisella tularensis

Francisella tularensis, the causative agent of tularemia, infects host macrophages, which triggers production of the proinflammatory cytokines interleukin 1 β (IL-1 β) and IL-18. We elucidate here how host macrophages recognize Francisella and elicit this pro-inflammatory response. Using mice defici...

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Autors principals: Fernandes-Alnemri, Teresa, Yu, Je-Wook, Juliana, Christine, Solorzano, Leobaldo, Kang, Seokwon, Wu, Jianghong, Datta, Pinaki, McCormick, Margaret, Huang, Lan, McDermott, Erin, Eisenlohr, Laurence, Landel, Carlisle P., Alnemri, Emad S.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111085/
https://ncbi.nlm.nih.gov/pubmed/20351693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1859
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