Limiting Ago protein restricts RNAi and microRNA biogenesis during early development in Xenopus laevis

We show that, in Xenopus laevis oocytes and early embryos, double-stranded exogenous siRNAs cannot function as microRNA (miRNA) mimics in either deadenylation or guided mRNA cleavage (RNAi). Instead, siRNAs saturate and inactivate maternal Argonaute (Ago) proteins, which are present in low amounts b...

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Bibliographic Details
Main Authors: Lund, Elsebet, Sheets, Michael D., Imboden, Susanne Blaser, Dahlberg, James E.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2011
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3110951/
https://ncbi.nlm.nih.gov/pubmed/21576259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.2038811
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