Limiting Ago protein restricts RNAi and microRNA biogenesis during early development in Xenopus laevis

We show that, in Xenopus laevis oocytes and early embryos, double-stranded exogenous siRNAs cannot function as microRNA (miRNA) mimics in either deadenylation or guided mRNA cleavage (RNAi). Instead, siRNAs saturate and inactivate maternal Argonaute (Ago) proteins, which are present in low amounts b...

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Bibliografiske detaljer
Main Authors: Lund, Elsebet, Sheets, Michael D., Imboden, Susanne Blaser, Dahlberg, James E.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2011
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3110951/
https://ncbi.nlm.nih.gov/pubmed/21576259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.2038811
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