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Limiting Ago protein restricts RNAi and microRNA biogenesis during early development in Xenopus laevis
We show that, in Xenopus laevis oocytes and early embryos, double-stranded exogenous siRNAs cannot function as microRNA (miRNA) mimics in either deadenylation or guided mRNA cleavage (RNAi). Instead, siRNAs saturate and inactivate maternal Argonaute (Ago) proteins, which are present in low amounts b...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3110951/ https://ncbi.nlm.nih.gov/pubmed/21576259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.2038811 |
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