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Protein stability by number: high-throughput and statistical approaches to one of protein science’s most difficult problems

Most proteins are only barely stable, which impedes research, complicates therapeutic applications, makes proteins susceptible to pathologically destabilizing mutations. Our ability to predict the thermodynamic consequences of even single point mutations is still surprisingly limited, and establishe...

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Detalhes bibliográficos
Main Authors: Magliery, Thomas J., Lavinder, Jason J., Sullivan, Brandon J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3110604/
https://ncbi.nlm.nih.gov/pubmed/21498105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2011.03.015
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