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Conditional FADD:GFP Knockout Mice Reveal FADD is Dispensable in Thymic Development but Essential in Peripheral T Cell Homeostasis

FADD/Mort1 is required for signaling induced by death-receptors such as Fas. In earlier studies, FADD-deficient mice died in utero and a FADD deficiency in embryonic stem cells inhibited T cell production in viable FADD(-/-)→RAG-1(-/-) chimeras. To analyze the temporal requirement of FADD in the dev...

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Sonraí Bibleagrafaíochta
Main Authors: Zhang, Yuhang, Rosenberg, Stephen, Hou, Ying-Ju, Imtiyaz, Hongxia Z., Zhang, Jianke
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2005
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3110086/
https://ncbi.nlm.nih.gov/pubmed/16116191
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