Correction of murine β-thalassemia after minimal lentiviral gene transfer and homeostatic in vivo erythroid expansion

A challenge for gene therapy of genetic diseases is to maintain corrected cell populations in subjects undergoing transplantation in cases in which the corrected cells do not have intrinsic selective advantage over nontransduced cells. For inherited hematopoietic disorders, limitations include ineff...

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Detalhes bibliográficos
Main Authors: Negre, Olivier, Fusil, Floriane, Colomb, Charlotte, Roth, Shoshannah, Gillet-Legrand, Beatrix, Henri, Annie, Beuzard, Yves, Bushman, Frederic, Leboulch, Philippe, Payen, Emmanuel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109707/
https://ncbi.nlm.nih.gov/pubmed/21436071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-01-263582
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