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Structural basis of fumarate hydratase deficiency

Fumarate hydratase catalyzes the stereospecific hydration across the olefinic double bond in fumarate leading to L-malate. The enzyme is expressed in mitochondrial and cytosolic compartments, and participates in the Krebs cycle in mitochondria, as well as in regulation of cytosolic fumarate levels....

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Autors principals: Picaud, Sarah, Kavanagh, Kathryn L., Yue, Wyatt W., Lee, Wen Hwa, Muller-Knapp, Susanne, Gileadi, Opher, Sacchettini, James, Oppermann, Udo
Format: Artigo
Idioma:Inglês
Publicat: Springer Netherlands 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109261/
https://ncbi.nlm.nih.gov/pubmed/21445611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10545-011-9294-8
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