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IL-12 Converts Foxp3(+) Regulatory T Cells to Foxp3(+)IFN-γ(+) T Cells with Inhibitory Functions During Induction of Colitis

Regulatory T (Treg) cells are plastic, but the in vivo mechanisms by which they are converted into Foxp3(+)interferon (IFN)-γ(+) T cells, and whether these converted cells retain the ability to inhibit colitis, are not clear. METHODS: Foxp3(+) Treg cells were generated by culture of naïve CD4(+) T c...

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Autores principales: Feng, Ting, Cao, Anthony T., Weaver, Casey T., Elson, Charles O., Cong, Yingzi
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109200/
https://ncbi.nlm.nih.gov/pubmed/21419767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.03.009
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