Expression of Sumoylation Deficient Nkx2.5 Mutant in Nkx2.5 Haploinsufficient Mice Leads to Congenital Heart Defects

Nkx2.5 is a cardiac specific homeobox gene critical for normal heart development. We previously identified Nkx2.5 as a target of sumoylation, a posttranslational modification implicated in a variety of cellular activities. Sumoylation enhanced Nkx2.5 activity via covalent attachment to the lysine re...

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Main Authors: Kim, Eun Young, Chen, Li, Ma, Yanlin, Yu, Wei, Chang, Jiang, Moskowitz, Ivan P., Wang, Jun
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3108998/
https://ncbi.nlm.nih.gov/pubmed/21677783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020803
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