Constitutive Smad linker phosphorylation in melanoma: A mechanism of resistance to Transforming Growth Factor-β-mediated growth inhibition

Melanoma cells are resistant to Transforming Growth Factor-β (TGFβ)-induced cell cycle arrest. In this study, we investigated a mechanism of resistance involving a regulatory domain, called linker region, in Smad2 and Smad3, main downstream effectors of TGFβ. Melanoma cells in culture and in tumor s...

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Hlavní autoři: Cohen-Solal, Karine A., Merrigan, Kim T., Chan, Joseph L.-K., Goydos, James S., Chen, Wenjin, Foran, David J., Liu, Fang, Lasfar, Ahmed, Reiss, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3108265/
https://ncbi.nlm.nih.gov/pubmed/21477078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1755-148X.2011.00858.x
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