Non-Canonical Smads Phosphorylation Induced by the Glutamate Release Inhibitor, Riluzole, through GSK3 Activation in Melanoma

Riluzole, an inhibitor of glutamate release, has shown the ability to inhibit melanoma cell xenograft growth. A phase 0 clinical trial of riluzole as a single agent in patients with melanoma resulted in involution of tumors associated with inhibition of both the mitogen-activated protein kinase (MAP...

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Autori principali: Abushahba, Walid, Olabisi, Oyenike O., Jeong, Byeong-Seon, Boregowda, Rajeev K., Wen, Yu, Liu, Fang, Goydos, James S., Lasfar, Ahmed, Cohen-Solal, Karine A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3470581/
https://ncbi.nlm.nih.gov/pubmed/23077590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047312
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