Non-Canonical Smads Phosphorylation Induced by the Glutamate Release Inhibitor, Riluzole, through GSK3 Activation in Melanoma

Riluzole, an inhibitor of glutamate release, has shown the ability to inhibit melanoma cell xenograft growth. A phase 0 clinical trial of riluzole as a single agent in patients with melanoma resulted in involution of tumors associated with inhibition of both the mitogen-activated protein kinase (MAP...

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Detalhes bibliográficos
Main Authors: Abushahba, Walid, Olabisi, Oyenike O., Jeong, Byeong-Seon, Boregowda, Rajeev K., Wen, Yu, Liu, Fang, Goydos, James S., Lasfar, Ahmed, Cohen-Solal, Karine A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3470581/
https://ncbi.nlm.nih.gov/pubmed/23077590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047312
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