Efficient induction of CD25(- )iTreg by co-immunization requires strongly antigenic epitopes for T cells

BACKGROUND: We previously showed that co-immunization with a protein antigen and a DNA vaccine coding for the same antigen induces CD40(low )IL-10(high )tolerogenic DCs, which in turn stimulates the expansion of antigen-specific CD4(+)CD25(-)Foxp3(+ )regulatory T cells (CD25(- )iTreg). However, it w...

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Autores principales: Geng, Shuang, Yu, Yang, Kang, Youmin, Pavlakis, George, Jin, Huali, Li, Jinyao, Hu, Yanxin, Hu, Weibin, Wang, Shuang, Wang, Bin
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107816/
https://ncbi.nlm.nih.gov/pubmed/21542943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-12-27
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