P38 MAP Kinase Signaling Is Required for the Conversion of CD4+CD25− T Cells into iTreg

CD4+CD25+ regulatory T cells (Treg) are important mediators of immune tolerance. A subset of Treg can be generated in the periphery by TGF-beta dependent conversion of conventional CD4+CD25− T cells into induced Treg (iTreg). In chronic viral infection or malignancy, such induced iTreg, which limit...

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Detalhes bibliográficos
Main Authors: Huber, Samuel, Schrader, Jörg, Fritz, Gerhard, Presser, Katrin, Schmitt, Steffen, Waisman, Ari, Lüth, Stefan, Blessing, Manfred, Herkel, Johannes, Schramm, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2553190/
https://ncbi.nlm.nih.gov/pubmed/18827879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003302
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