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Characterization of purified Sindbis Virus nsP4 RNA-dependent RNA Polymerase activity in vitro

The Sindbis virus RNA-dependent RNA polymerase (nsP4) is responsible for the replication of the viral RNA genome. In infected cells, nsP4 is localized in a replication complex along with the other viral non-structural proteins. nsP4 has been difficult to homogenously purify from infected cells due t...

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Detalhes bibliográficos
Main Authors: Rubach, Jon K., Wasik, Brian R., Rupp, Jonathan C., Kuhn, Richard J., Hardy, Richard W., Smith, Janet L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107704/
https://ncbi.nlm.nih.gov/pubmed/19036396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2008.10.030
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