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The Use of Chromatin Insulators to Improve the Expression and Safety of Integrating Gene Transfer Vectors
The therapeutic application of recombinant retroviruses and other integrating gene transfer vectors has been limited by problems of vector expression and vector-mediated genotoxicity. These problems arise in large part from the interactions between vector sequences and the genomic environment surrou...
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| Auteur principal: | |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Mary Ann Liebert, Inc.
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3107579/ https://ncbi.nlm.nih.gov/pubmed/21247248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2010.233 |
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