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A gold-catalyzed alkyne-diol cycloisomerization for the synthesis of oxygenated 5,5-spiroketals

A highly efficient synthesis of oxygenated 5,5-spiroketals was performed towards the synthesis of the cephalosporolides. Gold(I) chloride in methanol induced the cycloisomerization of a protected alkyne triol with concomitant deprotection to give a strategically hydroxylated 5,5-spiroketal, despite...

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Bibliografske podrobnosti
Main Authors: Tlais, Sami F, Dudley, Gregory B
Format: Artigo
Jezik:Inglês
Izdano: Beilstein-Institut 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107449/
https://ncbi.nlm.nih.gov/pubmed/21647322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.7.66
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