Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and micro-RNA levels

MK-0457 and MK-5108 are novel aurora kinase inhibitors (AKi) leading to G2/M cell cycle arrest. Growth and survival of multiple lymphoma cell lines were studied with either drug alone or in combination with vorinostat, an HDACi, using MTS and Annexin V assays, followed by molecular studies. Either A...

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Main Authors: Kretzner, Leo, Scuto, Anna, Dino, Pamela M., Kowolik, Claudia M., Wu, Jun, Ventura, Patrick, Jove, Richard, Forman, Stephen J., Yen, Yun, Kirschbaum, Mark H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107377/
https://ncbi.nlm.nih.gov/pubmed/21502403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2259
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