Učitavanje...
HIV DNA is heavily uracilated, which protects it from autointegration
Human immune cells infected by HIV naturally contain high uracil content, and HIV reverse transcriptase (RT) does not distinguish between dUTP and dTTP. Many DNA viruses and retroviruses encode a dUTPase or uracil-DNA glycosylase (UNG) to counteract uracil incorporation. However, although HIV virion...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2011
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3107311/ https://ncbi.nlm.nih.gov/pubmed/21576478 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102943108 |
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