HIV DNA is heavily uracilated, which protects it from autointegration

Human immune cells infected by HIV naturally contain high uracil content, and HIV reverse transcriptase (RT) does not distinguish between dUTP and dTTP. Many DNA viruses and retroviruses encode a dUTPase or uracil-DNA glycosylase (UNG) to counteract uracil incorporation. However, although HIV virion...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Yan, Nan, O'Day, Elizabeth, Wheeler, Lee Adam, Engelman, Alan, Lieberman, Judy
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2011
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107311/
https://ncbi.nlm.nih.gov/pubmed/21576478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102943108
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller