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HIV DNA is heavily uracilated, which protects it from autointegration
Human immune cells infected by HIV naturally contain high uracil content, and HIV reverse transcriptase (RT) does not distinguish between dUTP and dTTP. Many DNA viruses and retroviruses encode a dUTPase or uracil-DNA glycosylase (UNG) to counteract uracil incorporation. However, although HIV virion...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3107311/ https://ncbi.nlm.nih.gov/pubmed/21576478 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102943108 |
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