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Crystallization and preliminary X-ray diffraction analysis of kanamycin-binding β-lactamase in complex with its ligand

TEM-1 β-lactamase is a highly efficient enzyme that is involved in bacterial resistance against β-lactam antibiotics such as penicillin. It is also a robust scaffold protein which can be engineered by molecular-evolution techniques to bind a variety of targets. One such β-lactamase variant (BlaKr) h...

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Autors principals: Van de Water, Karen, Soror, Sameh H., Wohlkonig, Alexandre, van Nuland, Nico A. J., Volkov, Alexander N.
Format: Artigo
Idioma:Inglês
Publicat: International Union of Crystallography 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107148/
https://ncbi.nlm.nih.gov/pubmed/21636917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309111013832
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