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Enantioconvergent Synthesis of (+)-Aphanorphine via Asymmetric Pd-Catalyzed Alkene Carboamination

[Image: see text] A concise asymmetric synthesis of (+)-aphanorphine has been achieved via a new enantioconvergent strategy. A racemic γ-aminoalkene derivative is transformed into a 1:1 mixture of enantiomerically enriched diastereomers using an asymmetric Pd-catalyzed carboamination. This mixture i...

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Bibliografiske detaljer
Main Authors: Mai, Duy N., Rosen, Brandon R., Wolfe, John P.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107030/
https://ncbi.nlm.nih.gov/pubmed/21557571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol2009895
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