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A High Throughput Assay for Discovery of Bacterial β-Glucuronidase Inhibitors
CPT-11 is a widely-used anti-cancer drug that is converted in vivo to its active metabolite, SN-38. In the liver, enzymes detoxify SN-38 by coupling it to a glucuronidate moiety and this inactive compound (SN-38G) is excreted into the gastrointestinal tract. In the intestine, commensal bacteria conv...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Bentham Open
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3106358/ https://ncbi.nlm.nih.gov/pubmed/21643506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1875397301105010013 |
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