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Potential Repurposing of Known Drugs as Potent Bacterial β-Glucuronidase Inhibitors
The active metabolite of the chemotherapeutic irinotecan, SN-38, is detoxified through glucuronidation and then excreted into the gastrointestinal tract. Intestinal bacteria convert the glucuronidated metabolite back to the toxic SN-38 using β-glucuronidase (GUS), resulting in debilitating diarrhea....
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| 發表在: | J Biomol Screen |
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| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8284931/ https://ncbi.nlm.nih.gov/pubmed/22535688 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057112444927 |
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