INTERFERON-ALPHA MEDIATES THE DEVELOPMENT OF AUTOIMMUNITY BOTH BY DIRECT TISSUE TOXICITY AND THROUGH IMMUNE-CELL RECRUITMENT MECHANISMS

Interferon alpha (IFNα) is known to play a key role in autoimmunity, but the mechanisms are uncertain. Although the induction of autoimmunity by IFNα is consistent with primarily immuno-modulatory effects, the high frequency of non-autoimmune inflammation suggests other mechanisms. We used thyroidit...

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Главные авторы: Akeno, Nagako, Smith, Eric P., Stefan, Mihaela, Huber, Amanda K., Zhang, Weijia, Keddache, Mehdi, Tomer, Yaron
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3106338/
https://ncbi.nlm.nih.gov/pubmed/21402899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002631
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