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SNP detection and genotyping from low-coverage sequencing data on multiple diploid samples

Reductions in the cost of sequencing have enabled whole-genome sequencing to identify sequence variants segregating in a population. An efficient approach is to sequence many samples at low coverage, then to combine data across samples to detect shared variants. Here, we present methods to discover...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Le, Si Quang, Durbin, Richard
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3106328/
https://ncbi.nlm.nih.gov/pubmed/20980557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.113084.110
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