Recalibration of mapping quality scores in Illumina short-read alignments improves SNP detection results in low-coverage sequencing data

BACKGROUND: Low-coverage sequencing is a cost-effective way to obtain reads spanning an entire genome. However, read depth at each locus is low, making sequencing error difficult to separate from actual variation. Prior to variant calling, sequencer reads are aligned to a reference genome, with alig...

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Vydáno v:PeerJ
Hlavní autoři: Cline, Eliot, Wisittipanit, Nuttachat, Boongoen, Tossapon, Chukeatirote, Ekachai, Struss, Darush, Eungwanichayapant, Anant
Médium: Artigo
Jazyk:Inglês
Vydáno: PeerJ Inc. 2020
Témata:
Bioinformatics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7727374/
https://ncbi.nlm.nih.gov/pubmed/33354434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.10501
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