The stereochemical course of the first step of pre-mRNA splicing.
We have determined the effects on splicing of sulfur substitution of the non-bridging oxygens in the phosphodiester bond at the 5' splice site of a pre-mRNA intron. Pre-mRNAs containing stereochemically pure Rp and Sp phosphorothioate isomers were produced by ligation of a chemically synthesized mod...
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
1993
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| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC310585/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8265362/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/21.23.5456 |
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