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The stereochemical course of the first step of pre-mRNA splicing.

We have determined the effects on splicing of sulfur substitution of the non-bridging oxygens in the phosphodiester bond at the 5' splice site of a pre-mRNA intron. Pre-mRNAs containing stereochemically pure Rp and Sp phosphorothioate isomers were produced by ligation of a chemically synthesize...

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Библиографические подробности
Главные авторы: Maschhoff, K L, Padgett, R A
Формат: Artigo
Язык:Inglês
Опубликовано: 1993
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC310585/
https://ncbi.nlm.nih.gov/pubmed/8265362
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