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Characterization of the Glycosylation Occupancy and the Active Site in the Follow-on Protein Therapeutic: TNK-Tissue Plasminogen Activator
TNK-tPA products from the innovator and follow-on manufacturers were characterized and compared. All tryptic peptides including N-terminal, C-terminal and mutated peptides as well as the disulfide linked peptides were identified, with the demonstration of the same primary sequence and disulfide link...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3104925/ https://ncbi.nlm.nih.gov/pubmed/20552988 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac100956x |
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