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Characterization of the Glycosylation Occupancy and the Active Site in the Follow-on Protein Therapeutic: TNK-Tissue Plasminogen Activator

TNK-tPA products from the innovator and follow-on manufacturers were characterized and compared. All tryptic peptides including N-terminal, C-terminal and mutated peptides as well as the disulfide linked peptides were identified, with the demonstration of the same primary sequence and disulfide link...

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Detalhes bibliográficos
Main Authors: Jiang, Haitao, Wu, Shiaw-Lin, Karger, Barry L., Hancock, William S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104925/
https://ncbi.nlm.nih.gov/pubmed/20552988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac100956x
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