FATTY ACID TRANSDUCTION OF NITRIC OXIDE SIGNALING: Nitro-linoleic acid mediates protective effects through regulation of the ERK pathway

In vivo and in vitro studies revealed that nitroalkenes serve as protective mediators in the lung by inducing the cytoprotective enzyme heme oxygenase-1 (HO-1). LNO(2) increased HO-1 mRNA, protein and activity in cultured pulmonary epithelial cells treated with 5 to 50 μM LNO(2) and in lungs of rats...

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Detalhes bibliográficos
Main Authors: Iles, Karen E., Wright, Marcienne M., Cole, Marsha P., Welty, Nathan E., Ware, Lorraine B., Matthay, Michael A., Schopfer, Francisco J., Baker, Paul R.S., Agarwal, Anupam, Freeman, Bruce A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104854/
https://ncbi.nlm.nih.gov/pubmed/19133325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2008.12.001
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