Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice

Insulin, growth hormone (GH), and insulin-like growth factor–1 (IGF-1) play key roles in the regulation of β cell growth and function. Although β cells express the GH receptor, the direct effects of GH on β cells remain largely unknown. Here we have employed a rat insulin II promoter–driven (RIP-dri...

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Autors principals: Wu, Yingjie, Liu, Chengyu, Sun, Hui, Vijayakumar, Archana, Giglou, Pejman Raeisi, Qiao, Ruifang, Oppenheimer, Joshua, Yakar, Shoshana, LeRoith, Derek
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2011
Matèries:
Brief Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104750/
https://ncbi.nlm.nih.gov/pubmed/21555853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45027
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