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Oncogenic Ras/Src cooperativity in pancreatic neoplasia

Pancreas cancer is one of the most lethal malignancies and is characterized by activating mutations of Kras, present in 95% of patients. More than 60% of pancreatic cancers also display increased c-Src activity, which is associated with poor prognosis. Although loss of tumor suppressor function (for...

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Détails bibliographiques
Auteurs principaux: Shields, DJ, Murphy, EA, Desgrosellier, JS, Mielgo, A, Lau, SKM, Barnes, LA, Lesperance, J, Huang, M, Schmedt, C, Tarin, D, Lowy, AM, Cheresh, DA
Format: Artigo
Langue:Inglês
Publié: 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104672/
https://ncbi.nlm.nih.gov/pubmed/21242978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.589
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