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Structures of segments of α-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation

Aggregates of the protein α-synuclein are the main component of Lewy bodies, the hallmark of Parkinson's disease. α-Synuclein aggregates are also found in many human neurodegenerative diseases known as synucleinopathies. In vivo, α-synuclein associates with membranes and adopts α-helical confor...

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Bibliografski detalji
Glavni autori: Zhao, Minglei, Cascio, Duilio, Sawaya, Michael R, Eisenberg, David
Format: Artigo
Jezik:Inglês
Izdano: Wiley Subscription Services, Inc., A Wiley Company 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104229/
https://ncbi.nlm.nih.gov/pubmed/21462277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.630
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